Product research and development moves through various phases. One of those is evaluating resistance management.

“With any new compound, we start out by looking at its biological fit,” says Wayne Steele, DuPont Agricultural development representative in Fresno, Calif.

Resistance management comes later in the product development stage after a biological fit is established.

“The idea of evaluating a compound with an eye toward resistance management is probably no more prevalent today than it has ever been — but it is better understood now.”

Steele says resistance management is important to the utility of the product, as well as its longevity, “because there may not be alternative control strategies if there is buildup of resistance to a new compound.”

DuPont has an uncompromising commitment to resistance management, not only with new compounds, but with older, generic compounds.

“Resistance management is a growing part of the labeling process with both old and new compounds,” Steele says. “It’s not unusual to change use patterns on the label of generics to maintain their efficacy.”

Unfortunately, not all generic marketers have the same commitment, he notes, and that can make resistance management for a particular compound or class of chemistry more difficult for everyone.

The biggest challenge in resistance management is when a compound is considered best in its class by PCAs.

“Once a PCA realizes how effective a compound can be, it is difficult to move away from that material because it can be counted upon to work effectively. However, to maintain the efficacy of effective compounds, chemistry rotation is critical to avoid resistance.”

To avoid these situations, DuPont includes specific use patterns on the label. Labels are the law consultants must follow — and could be the law that saves a product for years of use.

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Copyright © 2006 E.I. du Pont de Nemours and Company. All Rights Reserved. 10/06